Statistical Mechanics and Stability of Macromolecules : Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

Statistical Mechanics and Stability of Macromolecules : Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

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Book Description
This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix,Earl Prohofsky,Cambridge University Press,0521451841,DNA,Dna (Deoxyribonucleic Acid),Life Sciences - Cytology,Macromolecules,Mathematical Statistics,Physics,Science,Science/Mathematics,Stability,Statistical mechanics,Statistical methods,Biochemistry,DNA--Stability--Statistical methods,Science / Physics

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